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19 March, 20:07

Put the steps of endochondral ossification in order

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  1. 19 March, 21:16
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    Step 1

    chondrocytes in the center of hyaline cartilage enlarge & form struts which begin to calcify. Then the enlarged chondrocytes die, leaving cavities in the cartilage

    Step 2

    Blood vessels grow around the edges of cartilage; cells in the perichondrium change to osteoblasts, producing a layer of superficial bone around the shaft which will continue to grow & become compact bone (appositional growth)

    Step 3

    Blood vessels enter the cartilage, bringing osteoblasts, spongy bone develops at the primary ossification center

    Step 4

    Remodeling creates a marrow cavity, bone replaces cartilage at the metaphyses

    Step 5

    Capillaries & osteoblasts enter the epiphyses, creating secondary ossification centers

    Step 6

    Epiphyses fill with spongy bone, cartilage remaining within the joint cavity is the articulation cartilage (Hyaline cartilage only in this phase)
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