Tolerance requires that you use more of the drug to achieve the same high or medical effect

true.

Explanation:

Tolerance is a term related to the use of medicines. It happens when your body, after taking the same medicine several times, develops a tolerance to the effect that that dose of medicine had on your body. As a result, you will need to take ever higher doses for the medicine to take effect on your body.

With that, we can say that it is true that tolerance requires you to use the medication to achieve the same high or medical effect.

True

Explanation:

the capacity to endure continued subjection to something, especially a drug, transplant, antigen, or environmental conditions, without adverse reaction. As your body gets used to something such as a drug it will take more to achieve the same high or effect.