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8 April, 15:10

If the allele frequency of the HbS allele is 0.3 in a population, what is the frequency of the HbA allele (assuming this is a two-allele system) ?

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  1. 8 April, 18:39
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    0.7

    Explanation:

    In solving Hardy Weinberg related question; we use the formula:

    p + q = 1 and/or

    p² + 2pq + q² = 1

    where:

    p = frequency of the dominant allele

    q = frequency of the recessive allele

    p² = frequency of individuals with the homozygous dominant genotype

    2pq = frequency of individuals with the heterozygous genotype

    q² = frequency of individuals with the homozygous recessive genotype.

    So, if p + q = 1

    and allele frequency of HbS = 0.3;

    Let the frequency of allele of HbS be (q) = 0.3 (since HbS is a recessive sickle cell traits)

    Let the frequency of allele of HbA be (p) = ? (since HbA is a normal hemoglobin)

    Then; to determine the allele of HbA; we have

    p+q = 1

    p + 0.3 = 1

    p = 1 - 0.3

    p = 0.7

    ∴ the frequency of the HbA allele = 0.7
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