In prokaryotes, certain proteins act to regulate genes by binding to DNA. What could be the effect of these binding proteins? Select all of the answers that apply.

A. They may act to turn on gene transcription.

B. They may act to turn off gene transcription.

C. They may become added to DNA, and then be transcribed.

D. They may remove a gene from DNA.

E. They may alter the nucleotide sequence in a gene.