There is a mutation in the rate limiting enzyme which prevents it from binding its substrate. How will this mutation affect the cholesterol biosynthetic pathway, when cholesterol levels are high in the organism?

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Biology

Susan Frank

22 February, 00:49

There is a mutation in the rate limiting enzyme which prevents it from binding its substrate. How will this mutation affect the cholesterol biosynthetic pathway, when cholesterol levels are high in the organism?

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Coleman Henderson · Answer 1

In the cholesterol biosynthetic pathway, the rate-limiting step is the reduction of HMG-CoA, which takes place in the existence of the HMG-CoA reductase enzyme. In case, when mutation takes place within the mentioned enzyme, it loses the tendency to combine with the substrate HMG-CoA, and as a consequence, the pathway fails to move forward and synthesis of cholesterol stops.

When the levels of cholesterol are high within the organism than the mutation of the enzyme HMG-CoA reductase results in less synthesis of cholesterol within the body of the organism and will eventually assist in balancing the level of cholesterol present within the body.