What do your cells have to overcome the problem of needing high activation energy?

Answer: They use enzymes.

Explanation:

Cells employ enzymes to drive and speed up their chemical reactions without being used up themselves. They are the only macromolecular biological catalysts that can start a reaction using the smallest available heat energy, thus overcoming the issue of needing high activation energy. Enzymes work by converting specific substrates to required product by binding them to their active site.