In aggressive forms of breast cancer, the gene encoding a protein called stathmin is overexpressed. Inhibiting expression of the stathmin gene arrests cells in M phase and is being investigated as an alternative therapy for treating cancer. What additional genes could be therapeutic targets that, when inactivated, would arrest cancerous cells in G1 phase?

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Biology

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11 June, 21:54

In aggressive forms of breast cancer, the gene encoding a protein called stathmin is overexpressed. Inhibiting expression of the stathmin gene arrests cells in M phase and is being investigated as an alternative therapy for treating cancer. What additional genes could be therapeutic targets that, when inactivated, would arrest cancerous cells in G1 phase?

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Jerry Harrison · Answer 1

Inactivating genes that code for cyclin proteins (in this case cyclins - type D) would arrest a cell in G1 phase. The type D cyclins are responsible for activating cyclin-dependent-kinases 4 and 6 responsible for the progression of a cell through the G1 phase to S phase.