Simon is working with his school newspaper to create the front page. What software is best used for page layout design?.

Adobe Indesign.

Explanation:

Adobe indesign is a typesetting and desktop publishing application used to create posters, newspapers, flyers, brochures, magazines, presentations, book and ebook etc.

It is a package from the Creative cloud adobe system packages. It has predetermined templates for newspaper pages (if newpaper is to published), and plug-ins to further customize the the layout of the newspaper to be created or published.