During world war ll which battle was the first significant us victory in the pacific

It was the Battle of Midway.

Japan wanted to take Midway in order to use it as a base to attack Pearl Harbor and force the US to sue for peace.

Didn't work.

The US took control of Midway, and the war turned in the US's favor.

During the Battle of Midway, the U. S. was able to inflict great losses on the Japanese army.