Which of the following was significant about the Declaration of Independence? It asserted that all the races were equal. It justified the reasons for changing government. It ended the practice of colonialism worldwide. It set up a government system without any leaders.

The phrase which explains what was significant about the Declaration of Independence was that it set up a government system without any leaders. This was sort of a system of emancipation from the British government for the thirteen colonies and this document essentially made the United States free from the rule of the British monarchy.