An energetic graduate student decides to do a voltage clamp experiment in which she clamps a single voltage gated-sodium channel and holds it at voltages ranging from - 100 to + 100 mV. Which of the following is she likely to observe? Assume ENa + = + 50 and EK + = - 70.
a. Sustained inward currents lasting several milliseconds would be detected from - 100 to + 100 mV
b. Transient inward currents of about 2 pA would be detected from - 100 to + 100 mV, but would be smallest in amplitude close to + 50mV
c. Transient outward currents would occur at + 70mV Correct
d. Transient currents would last longer and longer as the voltage was increased from + 10 to + 60 mV
e. None of the above
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