Selective breeding has been used for thousands

of years to

(1) develop bacteria that produce human insulin

(2) clone desirable plant varieties

(3) develop viruses that protect against diseases

(4) produce new varieties of domestic animals

(4) produce new varieties of domestic animals

Although (1) (2) and (3) are modern-day uses of selective breeding, they are relatively recent developments in human history, only used for the past century or less. (4) is correct because the selective breeding of domestic animals to produce new varieties of dogs, cats, etc. has been used for thousands of years, dating back to the ancient Chinese and Egyptian dynasties.