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1 March, 19:06

Why is replication on one strand of dna continuous, while on the other strand the replication must be discontinuous?

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  1. 1 March, 21:41
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    This is because DNA polymerase can only add new nucleotides in the 5’ to 3’ direction. In the replication bubble, the continuous strand is 5’-3’, however the discontinuous strand is 3’-5’. This forces DNA polymerase to use small primers and work backwards on the discontinuous strands, forming Okazaki fragments.
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