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10 October, 23:41

Tetracycline is an antibiotic that blocks the a site on prokaryotic ribosomes, thus preventing translation. why doesn't it prevent translation in eukaryotic ribosomes?

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  1. 11 October, 00:07
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    Prokaryotic and eukaryotic ribosomes have similar structures but they are different. Prokaryotic ribosomes are composed of a 50s and 30s subunit, while Eukaryotic ribosomes are composed of a 60s and 40s subunit. Tetracycline binds to the a site of the 30s subunit of Prokaryotes but cannot bind efficiently to the same site in the 40s subunit of eukaryotic ribosomes due to the differences in structure and sequence.
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