You are working with a 125 million bp human chromosome (1 centimorgan = 1 million bp), and wish to use markers to map newgenes via linkage. In theory, what are the minimum number of markers/loci you need to map genes to this chromosome? Why?

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Biology

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30 May, 15:35

You are working with a 125 million bp human chromosome (1 centimorgan = 1 million bp), and wish to use markers to map newgenes via linkage. In theory, what are the minimum number of markers/loci you need to map genes to this chromosome? Why?

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Answers (1)

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Barber · Answer 1

After every 0.192 centimorgan

Explanation:

If there are 125 million base pairs then according to the parallel ratio compare rule it should contain an average of 650 genes. If every gene has to be marked by a single marker on each end then a total number of 651 markers are used after every 0.192 centimorgan distance.