Histamines trigger dilation of nearby blood vessels, and increase in their permeability. Which of the signs ofinflammation are therefore associated with histamine release? A) redness and heat onlyB) swelling onlyC) painD) redness, heat, and swellingE) all of the signs of inflammation

The signs of inflammation that are associated with histamine release is the expression of redness, heat, swelling, and pain.

Explanation:

The basophil - mast cell product, histamine, is a part of the innate immune mechanism in the body of higher animals to fight foreign agents. Since these molecules are kind of protective measures in the body, they do not lead to loss of function of the affected part where they are localized, however, they do increase the vasodilation and permeability of the blood vessels to white blood cells, mainly neutrophils and macrophages to fight microbes, and consequently lead to swelling, redness, heat and pain which can also be due to the secretion of bradykinin. Therefore, inflammation due to histamine is associated with option E.