Refer to Animation: Proofreading in DNA Replication. What is the name for the enzyme activity that DNA polymerase has when it removes an improperly paired base from the end of the growing strand?

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Biology

Branden Hahn

11 December, 15:09

Refer to Animation: Proofreading in DNA Replication. What is the name for the enzyme activity that DNA polymerase has when it removes an improperly paired base from the end of the growing strand?

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Jerimiah Mckinney · Answer 1

Answer: Though the animation is not provided, proofreading in DNA replication is done by the 3'->5' exonuclease activity of DNA polymerase.

Explanation: Proofreading is a process by which the 3'->5' exonuclease activity of DNA polymerase double-checks each nucleotide after it is added and removes the mismatched nucleotide.

When a wrong nucleotide is added during replication, translocation of the DNA polymerase to the position where the next nucleotide is to be added is inhibited until the 3'->5' exonuclease activity of DNA polymerase double-checks and removes the incorrectly paired nucleotide so that the polymerase can begin replication again.