You are studying the effects of specific transcription factors on the activation of gene expression. You notice that one particular transcription factor binds far away from the promoter of its target gene. What can explain this?

The answer is the flexibility of DNA.

Explanation:

The flexibility os DNA is what allows transcription factors at distant binding sites to do their job. The DNA loops like cooked spaghetti to bring far-off binding sites and transcription factors close to general transcription factor or mediator proteins.