Large-scale cancer studies have found that the p53 gene is often mutated in tumor cells. In fact, the gene encoding the p53 protein is mutated in tumor cells more often than any of the other 20,000 human genes. Based on this information, why was the Bunz study important?

Question

Biology

Clark Blevins

12 July, 21:33

Large-scale cancer studies have found that the p53 gene is often mutated in tumor cells. In fact, the gene encoding the p53 protein is mutated in tumor cells more often than any of the other 20,000 human genes. Based on this information, why was the Bunz study important?

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Answers (1)

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Hailie Spence · Answer 1

The study revealed the importance of p53 to the arrest of cell cycle, preventing DNA failure

Explanation:

The study from 1998 called "Requirement for p53 and p21 to sustain G2 arrest after DNA damage" shows that cells that could sustain G2 arrest, before mitosis, because of some DNA damage, were the cells with active p53 protein and in other cells gamma ray irradiated (provoking DNA damage), progression through the cell cycle was possible, which gives the idea of p53 be essential to guarantee that the DNA content in the nucleus is correct.