A cell has been subjected to X-ray irradiation, causing a significant number of mutations in the genome. Which of the following would you NOT expect to occur as a result?

(A) Activation of the protein kinase ATR

(B) Activation of the protein kinase Chk1

(C) Inactivation of the protein phosphatase Cdc25

(D) Binding of p53 to Mdm2

(E) Stabilization of p53

(D) Binding of p53 to Mdm2

Explanation:

Radiation can be very dangerous, as it has the ability to promote mutations in cells that can trigger physical anomalies that will bring great discomfort to the body. X-ray irradiation is not an exception and is capable of causing a significant number of mutations in the genome.

In relation to the question above, radiation X does not promote the binding of p53 to Mdm2, on the contrary, radiation causes the dissociation of these two systems. In addition, it causes the protein kinase ATR and Chk kinase to be deactivated, the protein phosphatase inactivation Cdc25 and p53 to stabilize.

D. Binding of p53 to Mdm2

It has nothing to do with Xray irradiation.

Explanation:

Mdm2 is a protein regarded as the main regulator of tumor suppressor protein P53. P53 Inactivation by mutation is seen as one of the most frequent alterations in tumors that affects humans.

The central binding p53 site of Mdm2 encloses amino acid. The binding of p53 to the central Domain is strengthened after the process of phosphorylation of the central Mdm2 domains.