Axl is a receptor tyrosine kinase that is highly upregulated in cancer cells. Your PI is interested in generating a new therapeutic against this receptor, turning it into a start-up idea, and making millions off of the potential product. They want you to spearhead this product, and you (unwillingly) decide to go along with the plan.
a. Your PI wants you to come up with a couple of different mechanisms on how to inhibit Axl. Propose one of those methods to target the drug specifically to cancer cells.
b. After trying to find DNA probes to target AXL tumors, you then have a realization that it's impossible. What makes cancer more difficult to diagnose with DNA probes than mendelian diseases (i. e., cystic fibrosis, sickle cell anemia, etc.) ?
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