Would you expect an enzyme designed to bind to its target substrate as tightly as it binds the reaction transition state to show a rate enhancement over the uncatalyzed reaction? In other words, would such a protein actually be a catalyst? Explain why or why not.

such protein cannot act as catalyst.

Explanation:

Enzymes are biological catalyst that complementary binds to the transition state of a reaction to decrease the activation energy thus enhancing the reaction rate.

If the a protein binds substrate as tightly it binds to the reaction transition state then protein cannot act as enzyme because enzymes never bind substrate tightly.