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29 November, 07:57

People with the genetic disorder Xeroderma pigmentosum

a. have no direct DNA repair mechanisms.

b. cannot repair UV induced DNA damage

c. do not express mismatch repair proteins.

d. fail to activate DNA strand break repair

e. have mutations within several DNA glycosylases.

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  1. 29 November, 08:58
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    b. cannot repair UV induced DNA damage

    Explanation:

    Xeroderma pigmentosum (XP) is a rare condition that is transmitted from parents to children. XP makes the skin and tissue covering the eye extremely sensitive to ultraviolet (UV) light. Some people also have problems in the nervous system.

    XP is an autosomal recessive inherited disorder. This means that you must have 2 copies of an abnormal gene for the disease or trait to manifest itself. The disorder is inherited from both the mother and the father at the same time. The abnormal gene is rare, so the chances of both parents having it are very rare. For this reason, it is very unlikely that a person with this condition will transmit it to the next generation, although it is a possibility.

    UV light, such as that found in sunlight, damages the genetic material (DNA) in skin cells. Normally, the body repairs this damage. However, in people suffering from XP, the body does not repair this damage. As a result, the skin becomes very thin and spots of varied colors appear (mottled pigmentation)
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