A client has had cholestyramine added to his or her treatment plan for dyslipidemia. What effect will cholestyramine have on the pharmacokinetics of the thiazide diuretic that the client is currently prescribed?

decrease absorption

Explanation:

Cholestyramine has been discovered to cause serum aminotransferase elevations in some cases when combined with thiazide diuretics. This is because the cholesyramine is not absorbed, hence it becomes surprising that it have been discovered to cause asymptomatic serum enzyme elevations.