HIV's genome of RNA includes the code for reverse transcriptase (RT), an enzyme that acts early in infection to synthesize a DNA genome off of an RNA template. The HIV genome also codes for protease (PR), an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogs (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR. Which mechanism produces variation for evolution by shuffling existing alleles? (a) Use a series of NAs, one at a time, and change about once a week. (b) Use a single PI, but slowly increase the dosage over the course of a week. (c) Use high doses of NA and a PI at the same time for a period not to exceed one day. (d) Use moderate doses of NA and two different PIs at the same time for several months.

Question

Biology

Terry Liu

23 March, 14:05

HIV's genome of RNA includes the code for reverse transcriptase (RT), an enzyme that acts early in infection to synthesize a DNA genome off of an RNA template. The HIV genome also codes for protease (PR), an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogs (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR. Which mechanism produces variation for evolution by shuffling existing alleles? (a) Use a series of NAs, one at a time, and change about once a week. (b) Use a single PI, but slowly increase the dosage over the course of a week. (c) Use high doses of NA and a PI at the same time for a period not to exceed one day. (d) Use moderate doses of NA and two different PIs at the same time for several months.

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Daniels · Answer 1

Use high doses of NA and a PI at the same time for a period not to exceed one day

Explanation:

The genetic material in viruses have mutations that will make Nucleoside analog ineffective, because of this the reverse transcriptase replicates the viral DNA.

The protease in inhibited by protease inhibitors. Protease acts on long viral polyproteins into smaller, functional proteins.

Nucleoside analogs acts against both these enzymes.

The mutation caused will make virus ineffective to NA and this occurs by sexual reproduction.

The allele frequency change due to mutations.

Use high doses of NA and a PI at the same time for a period not to exceed one day it will yield mutated viruses