Which of the following statements are correct with regards to sulfamethoxazole/trimethoprim?

A. It is a potent hepatic enzyme inducer resulting in reduced drug concentrations.

B. It has excellent bioavailability, thus can transition from intravenous to oral formulations in a 1:1 fashion.

C. It is active against many Gram-positive pathogens, including Staphylococci, Gram-negative pathogens, and opportunistic pathogens.

D. This drug should be used with caution in a patient with G6PD deficiency.

E. A negative Coombs test with sulfamethoxazole/trimethoprim indicates hemolytic anemia

Answer: The following statements are correct with regards to sulfamethoxazole/trimethoprim

B.) It has excellent bioavailability, thus can transition from intravenous to oral formulations in a 1:1 fashion.

C.) It is active against many Gram-positive pathogens, including Staphylococci, Gram-negative pathogens, and opportunistic pathogens.

D.) This drug should be used with caution in a patient with G6PD deficiency.

Explanation:

sulfamethoxazole/trimethoprim is an antibiotic used for the treatment of many bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazole and therefore is also called co-trimoxazole.

A positive Coombs test with sulfamethoxazole/trimethoprim indicates hemolytic anemia therefore should be discontinued. It is a potent hepatic enzyme inhibitor (not inducer).

Answer:B