Whiat signals induces the disassembly of the nuclear lamina?

Answer: Phosphorylation of mitotic sites at the start of mitosis (N-terminal S22 and C-terminal S392 in human lamin A/C)

Explanation: During mitosis the nuclear lamina is dissociated by phosphorylation - dependent mechanisms that causes conformational changes in structure at N - and C-terminals (non alpha helical terminals) during the start of cellular mitosis that leads to its disassembly. This is because the nuclear lamina has two sites that accept phosphates (phosphoacceptor sites) causing a phosphorylation reaction.

The nuclear lamina is a fibrillar network of intermediate filaments as well as membrane proteins and are involved in DNA replication, cellular division as well as providing mechanical support within the cell.