Which of the following statements about 2,3-bisphosphoglycerate (BPG) binding is FALSE?

(A) BPG binds less tightly to fetal hemoglobin than to adult hemoglobin, thereby aiding oxygen transfer to a fetus.

(B) BPG binds to hemoglobin at one site and lowers hemoglobin's affinity for oxygen at another site.

(C) BPG aids oxygen delivery to tissues by increasing the affinity of myoglobin for oxygen.

(D) BPG requires a binding site containing multiple positively charged groups.

The answer is C: BPG aids oxygen delivery to tissues by increasing the affinity of myoglobin for oxygen.

Explanation:

2,3-Bisphosphoglycerate (2,3-BPG) or BPG controls the affinity for haemoglobin to oxygen and not myoglobin. Myoglobin is a monomer, where as haemoglobin is a tetramer hence BPG cannot have an effect on myoglobin.

The answer is C. BPG aids oxygen delivery to tissues by increasing the affinity of myoglobin for oxygen

Explanation:

The 2,3-bisphosphoglycerate (BPG) which can also be referred to as the 2,3 - di phosphoglycerate, is being produced by the red cells and has the ability to deoxygenate hemoglobin. This is because, his accumulation results to a decrease in the affinity for oxygen, this means that, it will convert hemoglobin to a low oxygen affinity state.

In this case, comparing the options given, it will be concluded that, 2,3 - biphosphoglycerate {BPG} does not aids the delivery of oxygen to tissues, but decreases the affinity of oxygen, which deoxygenate hemoglobin, and causes the concentration of the carbon dioxide to increase.