The transmission of G-protein-coupled receptors involves only two steps: binding to the receptor protein and activation of G-proteins. True or false?

False

Explanation:

G-Protein Coupled Receptors (GPCR):

GPCRs are transmembrane receptors with three components:

Extracellular domain for ligand binding Seven transmembrane helices Intracellular G-protein binding domain

Transmission Through GPCRs:

A ligand binds to the extracellular domain of the GPCR. The GPCR undergoes conformational changes. This conformational change activates the G-protein by replacing its bound GDP (guanosine diphosphate) with GTP (guanosine triphosphate). The G-protein then loses its GTP bound alpha subunit which activates the adenylyl cyclase system.