The transmission of G-protein-coupled receptors involves only two steps: binding to the receptor protein and activation of G-proteins. True or false?

Question

Biology

Rosemary Montoya

9 November, 07:25

The transmission of G-protein-coupled receptors involves only two steps: binding to the receptor protein and activation of G-proteins. True or false?

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Answers (1)

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Cheerio · Answer 1

False

Explanation:

G-Protein Coupled Receptors (GPCR):

GPCRs are transmembrane receptors with three components:

Extracellular domain for ligand binding Seven transmembrane helices Intracellular G-protein binding domain

Transmission Through GPCRs:

A ligand binds to the extracellular domain of the GPCR. The GPCR undergoes conformational changes. This conformational change activates the G-protein by replacing its bound GDP (guanosine diphosphate) with GTP (guanosine triphosphate). The G-protein then loses its GTP bound alpha subunit which activates the adenylyl cyclase system.