How do large molecules move across the plasma membrane

The plasma membrane is selectively permeable

Explanation:

hydrophobic molecules and small polar molecules can diffuse through the lipid layer, but ions and large polar molecules cannot. Integral membrane proteins enable ions and large polar molecules to pass through the membrane by passive or active transport.

By passive or active transport

Explanation:

Integral membrane proteins enable ions and large polar molecules to pass through the membrane by passive or active transport.