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15 January, 02:08

People with beriberi, a disease caused by thiamine deficiency, have elevated levels of blood pyruvate and a - ketoglutarate, especially after consuming a meal rich in glucose. How are these effects related to a deficiency of thiamine?

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  1. 15 January, 05:29
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    Thiamine pyrophosphate is a thiamine derivative and acts a coenzyme for various enzymes including pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. These are involved in catabolism of pyruvate and α-ketoglutarate, respectively.
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