Mutation rates per nucleotide per replication:

- are higher in organisms with larger genomes

- are highest in viruses.

- are lower in organisms with larger genomes.

- are similar across all organisms.

- are highest in bacteria.

The correct answer will be option-are highest in viruses.

Explanation:

The mutation is a change or alteration in the nucleotides of a DNA which is the coding molecule of the organisms. Mutations are known as the building blocks of the evolution which introduces variation upon which the natural selection act.

The mutation takes place in every organism on earth but the highest rate of mutation per nucleotide is observed in the RNA viruses which are involved with the adaptability and virulence. The mutation rate is million times higher than their hosts and a small increase in the mutation rate can make them extinct.

Thus, the selected option is the correct answer.