Which statement about the tumor suppressor gene p53 is false?

(A) It is required for apoptosis in response to DNA damage.

(B) It blocks cell cycle progression in response to DNA damage.

(C) It plays a role in up to 50% of human cancers.

(D) Its loss causes retinoblastoma, a rare childhood cancer of the eye.

Question

Biology

Elliot Jackson

16 August, 19:03

Which statement about the tumor suppressor gene p53 is false?

(A) It is required for apoptosis in response to DNA damage.

(B) It blocks cell cycle progression in response to DNA damage.

(C) It plays a role in up to 50% of human cancers.

(D) Its loss causes retinoblastoma, a rare childhood cancer of the eye.

+5

Answers (1)

Know the Answer?

Brodie Fletcher · Answer 1

The correct answer is D its loss causes retinoblastoma a rare childhood cancer of the eye.

Explanation:

p53 is one of the most important tumor suppressor protein. It is named so because it has a molecular weight of 53 kd. p53 is encodes by TP53 gene. p53 play a significant role during apoptosis or programmed cell death.

But the mutation in p53 does not cause retinoblastoma. Retinoblastoma is caused due to mutation in Retinoblastoma tumor suppressor protein. This disease is formed when both the allele of the retinoblatoma gene gets mutated.