Which of the following predictions is a plausible explanation for how ADP activates isocitrate dehydrogenase? A. When binding to isocitrate dehydrogenase, ADP decreases the Km for isocitrate. B. When binding to isocitrate dehydrogenase, ADP increases the Km for isocitrate. C. When binding to isocitrate dehydrogenase, ADP dephosphorylates the enzyme. D. When binding to isocitrate dehydrogenase, ADP phosphorylates the enzyme.

Question

Biology

Corey Davenport

18 August, 20:30

Which of the following predictions is a plausible explanation for how ADP activates isocitrate dehydrogenase? A. When binding to isocitrate dehydrogenase, ADP decreases the Km for isocitrate. B. When binding to isocitrate dehydrogenase, ADP increases the Km for isocitrate. C. When binding to isocitrate dehydrogenase, ADP dephosphorylates the enzyme. D. When binding to isocitrate dehydrogenase, ADP phosphorylates the enzyme.

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Answers (1)

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Blake Velazquez · Answer 1

A. When binding to isocitrate dehydrogenase, ADP decreases the Km for isocitrate.

Explanation:

when ADP decreases the Km, it causes isocitrate dehydrogenase to have higher affinity for its substrate and as such can attain Vmax (The rate of reaction when the enzyme is saturated with substrate is the maximum rate of reaction) easily and faster, that is activation.