The following are important steps in the process of endochondral ossification. What is the correct order for these events? 1. Enlarged chondrocytes die. 2. Osteoblasts replace calcified cartilage with spongy bone. 3. Chondrocytes enlarge and the surrounding matrix begins to calcify. 4. Blood vessels grow around the edges of the cartilage. 5. Perichondrial cells become osteoblasts and produce a superficial layer of bone.

The procedure by which the developing cartilage systematically gets substituted by the bone to produce the growing skeleton is termed as endochondral ossification. The columns of chondrocytes are after that get invaded by the metaphyseal blood vessels, and on the residual columns of the calcified cartilage the formation of bone takes place.

The following are the essential steps in the procedure of endochondral ossification:

1. The chondrocytes get enlarged and the enveloping matrix starts to calcify.

2. The enlarged chondrocytes die.

3. The growth of the blood vessels takes place surrounding the edges of the cartilage.

4. The perichondrial cells turn into osteoblasts and generate a superficial bone layer.

5. The osteoblasts substitute the calcified cartilage with the spongy bone.