Which cellular structure makes it possible for a cell to differ structurally and biochemically from its surroundings?

A plasma membrane is the cellular structure that makes it possible for a cell to differ structurally and biochemically from its surroundings.

Explanation:

Plasma membrane is the surrounding of all the cells. The function of plasma membrane in a cell is to regulate the incoming and outgoing elements from the cell.

Phospholipid bilayer is the main composition of plasma membrane. It makes the cell different from each other structurally as well as makes the cell different in chemical composition too.