The net equation for the oxidative reactions of the pentose phosphate pathway is

glucose-6-phosphate+2NADP + + H2O---> ribulose-5-phosphate+2NADPH+CO2+2H+

Determine which of the following statements about the pentose phosphate pathway are true.

Products of the pentose phosphate pathway contribute to reductive biosynthesis reactions

Pentose phosphate pathway actiivtiy is high in rapidliy diving cells.

Glucose-6-phosphate is reduced to ribulose-5-phosphate in ths series of reactions.

Glucose-6-Phospjate is common to glycolysis and the pentose phosphate pathway

Products of the pentose phosphate pathway contribute to reductive biosynthesis reactions

Pentose phosphate pathway activity is high in rapidly diving cells.

Glucose-6-Phospjate is common to glycolysis and the pentose phosphate pathway

Explanation:

Glycolysis is the major catabolic fate of glucose 6-phosphate. However, oxidation of glucose 6-phosphate to pentose phosphates occurs by the pentose phosphate pathway. Therefore, glucose 6-phosphate is common to glycolysis and pentose phosphate pathway.

Pentose phosphate pathway uses NADP + as an electron acceptor, yielding NADPH. Rapidly dividing cells, such as the cells of bone marrow and skin use the pentoses as one of the precursors for the synthesis of RNA, DNA, and coenzymes like NADH, FADH2, and coenzyme A.

The NADPH formed during pentose phosphate pathway is needed for reductive biosynthesis by many tissues. For instance, liver and adipose tissues carry out the extensive synthesis of fatty acid and require NADPH. Likewise, the tissues involved in the active synthesis of cholesterol and steroid hormones (for example, adrenal gland and gonads) also require the NADPH which in turn is provided by the pathway.