For a folding domain that forms a sort of "fist" with certain amino acid R groups buried within and other R groups facing out, the hydrophobic R groups mainly face "out" and the hydrophilic R groups mainly face "in."True / False.

False

Explanation:

The proteins whose R groups ionize at different pHs to obtain either a positive or negative charge are hydrophilic and due to this, they are attracted to the water molecules. The R groups of hydrophilic proteins contain either acidic or basic amino acids. The hydrophobic proteins are repelled by water and their R group consists of nonpolar amino acids. When the proteins form a fist like structure, their hydrophobic R groups are hidden inside the fist whereas the hydrophilic R groups face out as it allows the hydrophilic groups to interact with the water molecules in the environment and thus, the protein obtains a stable structure.