Many types of cancer are known to overexpress the receptor protein tyrosine kinase. Which molecular technique can be used to reduce expression of tyrosine kinase in cell culture?

By phosphorylation or by activating cyclin-dependent kinase-mediated signaling pathways

Explanation:

The Cyclin-Dependent Kinases (Cdks) are a family of critical regulatory proteins capable of modulating the progression through the cell cycle. Cdks are in turn regulated by binding to cyclin proteins or by phosphorylation at specific amino acid residues (generally tyrosine and threonine).

Phosphorylation is the most widely studied posttranslational modification and it is known to inhibit (and also activate) protein function, while cyclin-dependent kinases are proteins known to inhibit the activity of Cdks and thereby acting as tumor suppressors by inducing cell death-apoptosis.