How does histone acetylation prepare DNA for transcription? Histones and DNA have opposite charges. Acetylation of histones cancels their positive charge. Acetylated histones are more attracted to DNA. Acetylation creates binding sites for remodeling engines and other factors.

Answer: Histones and DNA have opposite charges - True

Acetylation of histones cancels their positive charge - True

Acetylated histones are more attracted to DNA - False

Acetylation creates binding sites for remodeling engines and other factors - True

Explanation:

It is widely found that acetylation of lysines leads to transcriptional activation. The modifications of histones such as acetylation affect the affinity of the histone for interacting proteins that control the transcriptional activity of chromatin, which has led to the concept of a histone code. The positive charge on the histones is removed by acetylation, hence they decrease the interaction of histones with the negatively charged phosphate groups of DNA. As a result, the highly condensed chromatin is now transformed to a more relaxed structure and thereby higher level of transcription are achieved