Can mRNA coding for a protein destined to be embedded in the plasma membrane associate with rough ER prior to the initiation of translation?

mRNA must start membrane protein in the cytoplasm and, after that, continue it in the rough ER.

Explanation:

Protein synthesis is initiated when mRNA meets a free ribosome, the primary structure for protein synthesis. Ribosomes can be found in the rough endoplasmic reticulum or floating in the cytosol. They read the mRNA code and add the correct amino acid using transference RNA to build the protein.

The rough endoplasmic reticulum is in charge of the synthesis and transport of the membrane proteins. It is also in charge of the latest protein modifications after transduction. Synthesis of membrane proteins starts in the cytoplasm with the production of a molecule portion known as a signal sequence. This portion leads the synthesizing protein and associated ribosome to a specific region in the Rough endoplasmic reticulum where it continues the protein building.

Membrane proteins are synthesized in the endoplasmic reticulum and sent to the Golgi complex in vesicles, where it happens the final association of carbohydrates with proteins. Finally, protein is transported from the Golgi complex to its final destiny, the membrane.