Mutations in what gene are most respoonsible for damaging oxidative for damaging oxidative stress in ALS?

a. SOD1

b. catalase

c. tau

d. alpha-synuclein

SOD1.

Explanation:

Amyotrophic lateral sclerosis (ALS) may be defined as a type of neurodegenreative disorder in which motor neurons are lost. This disease mainly occur due to mutation in the anti-oxidant enzyme.

Superoxide dismutase type1 (SOD1) is an anti-oxidative enzyme, its mutation may result in the ALS disease. This gene is responsible for damaging oxidative stress in ALS.

Thus, the correct answer is option (a).