Neurofibrillary tangle in AD are primarily due to mis-folding of what protein?

a. beta-amyloid

b. tau

c. alpha-synuclein

d. SOD1

Answer: Tau

Explanation:

NFTs or neurofibrillary tangles are insoluble twisted fibers. The tangles are abnormal accumulation that collect inside neurons. Their presence is also found in other diseases such as tauopathies. Statins have been shown to reduce neurofibrillary tangles in mouse models. Lithium has been shown to decrease the phosphorylation of tau. The tau protein is primary maker Alzheimer's disease.