Explain why it would be logical that the intracellular concentration of many molecules is near the Km of the enzymes for which they are substrates.

The intracellular is where enzymes need to perform optimally or near optimum.

Explanation:

The Km is the concentration of molecules where an enzyme performs at half of its maximum velocity (Vmax). Therefore, when molecules are near Km the enzyme is able to hydrolyze molecules nearer its Vmax.