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13 August, 16:15

How are cancer therapies tailored to nucleotide synthesis - explain using the example of fluorouracil and methotrexate.

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  1. 13 August, 19:30
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    By preventing the synthesis of DNA halting cell growth.

    Explanation:

    Fluorouracil and methotraxate prevent the synthesis of the neucleoside Thymidine thus preventing DNA replication and elongation. Methotraxate has a structure analogous to Folic acid which is important for thymidine synthesis. Thus, it acts as a competitive inhibitor on dihdrofolate reductase an enzyme that is essential for tetrahydrofolate formation, a folic acid derivative.

    Fluorouracil acts by inhibiting thymidylate synthase which catalyses an essential step in Thymidine synthesis.
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