A protein called RB normally blocks cell cycle progression from G1 to S. Phosphorylation inactivates RB. Which of the following, related to RB and its function, might result in a cell turning cancerous?
(A) increase in RB levels
(B) loss of RB phosphorylation
(C) overproduction of kinases that phosphorylate RB
(D) inactivation of the DNA replication machinery in S
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