The pyruvate dehydrogenase (PDH) complex catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and CO 2. CO2. Multiple copies of pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2), and dihydrolipoyl dehydrogenase (E3) along with five cofactors form the PDH complex. Biochemists have studied the PDH complex for decades, in part due to its interesting use of substrate channeling during catalysis. What is the benefit of substrate channeling?

The PDH active site forms in the hydrophobic core of the complex instead of a surface-exposed region.

Reaction progress is not limited by the diffusion constant.

Intermediates of a multistep reaction sequence do not dissociate from the enzyme complex.

The PDH complex sequesters excess substrate to use at later time.

Every intermediate or product made by the PDH complex enters the citric acid cycle as a substrate.

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Biology

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25 March, 22:43

The pyruvate dehydrogenase (PDH) complex catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and CO 2. CO2. Multiple copies of pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2), and dihydrolipoyl dehydrogenase (E3) along with five cofactors form the PDH complex. Biochemists have studied the PDH complex for decades, in part due to its interesting use of substrate channeling during catalysis. What is the benefit of substrate channeling?

The PDH active site forms in the hydrophobic core of the complex instead of a surface-exposed region.

Reaction progress is not limited by the diffusion constant.

Intermediates of a multistep reaction sequence do not dissociate from the enzyme complex.

The PDH complex sequesters excess substrate to use at later time.

Every intermediate or product made by the PDH complex enters the citric acid cycle as a substrate.

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Answers (1)

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Jerimiah Pena · Answer 1

Answer:Intermediates of a multistep reaction sequence do not dissociate from the enzyme complex.

Explanation:

Substrate channeling is the moving of intermediate metabolic product of one enzyme to another enzyme without it be lost to another enzyme.

Channeling makes metabolic pathway more fast and efficient that it will be when the enzyme are at random.

It avoid the use up of intermediate formed by other reaction catalyze by another enzyme.

For pyruvate dehydrogenase channeling prevent the intermediate from dissolving and been used up by other reaction.