Altering the three-dimensional structure of an enzyme might

The question is incomplete as it does not have the option which are:

change the amount of energy needed for a reaction. prevent the substrate from binding the enzyme's active site. change the type of substrate that binds the enzyme's active site. change the type of product produced in the reaction. prevent the enzyme from adding energy to a reaction

Answer

prevent the substrate from binding the enzyme's active site.

Explanation:

An Enzyme is a molecule composed of the amino acids in a 3 D conformation which catalyze or speed up a reaction.

The enzyme protein catalyses a chemical reaction by binding the substrate to its active pore formed by the 3D conformation of the protein and forming a complex of the substrate and enzyme.

If the 3D conformation of the enzyme is changed or altered then the active pore will be disrupted as a result of which the substrate-binding affinity and specificity will be changed which will not the reaction to proceed in forwarding direction or other terms the functionality of the protein will be lost.

Thus, the selected option is correct.