What are some possible short and long term medical concerns for crew members on longer space exploration trips

During longer space exploration trips, all of the medical concerns are due to the absence of gravitational force. Crewmembers may develop short-term conditions which are reversible. Those conditions include: vision impairment risks and short-term cardiac atrophy, increase in length, weight loss, vestibular dysfunction etc.

On the other side, the long-term medical condition is loss of bone mineral density (negative calcium balance) and radiation exposure which are irreversible.