A yeast strain has a temperature sensitive mutation in the SRP receptor. At low temperatures, the SRP receptor functions normally. At elevated temperatures, the SRP receptor is marked for proteolytic destruction. If you shifted a culture of this yeast strain to elevated temperatures, what would be the immediate impact on proteins that are normally co-translationally inserted into ER?

Question

Biology

Suzan

1 June, 15:16

A yeast strain has a temperature sensitive mutation in the SRP receptor. At low temperatures, the SRP receptor functions normally. At elevated temperatures, the SRP receptor is marked for proteolytic destruction. If you shifted a culture of this yeast strain to elevated temperatures, what would be the immediate impact on proteins that are normally co-translationally inserted into ER?

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Amorcita · Answer 1

Immediate observation would be denatured proteins

Explanation:

Proteins gain their structural integrity from their tertiary structure. There are some structural amino acids such as proline that provide a rigidity to proteins that allow it to maintain it's shape through various biotic and abiotic changes.

In heat sensitive mutations the protein sequences that are responsible for structural maintenance are lost or compromised. This causes immediate loss of function once the protein is outside of it's ideal environment.